Age 73, passed away on January 4, 2022, at home surrounded by her loving family after a courageous battle with cancer. She was born in Kalamazoo on April 3, 1948, the daughter of the late William and Mary Jane (DeSmit) Johnson. She was also preceded in death by a brother, Daniel Johnson. Karen was kind, generous and loving. She worked hard as a secretary for the Kalamazoo Public School system. When not working she enjoyed baking, gardening, going shopping and playing cards. She believed in the Lord and attended the Methodist church. More than anything, Karen enjoyed being a mother, grandmother and great-grandmother. She leaves behind many wonderful memories of a life well lived and she will be missed by all who loved her. She is survived by four children, Brian Mayne, Amy Gruver, Rebecca Mayne and Sarah Guritz; fourteen grandchildren and fifteen great-grandchildren; three siblings, Larry, Ron and Bill Johnson; a sister-in-law, Connie Johnson; many nieces, nephews and friends.